Publications

DeWorm3 publishes in open-source, peer-reviewed journals regularly. This page is maintained with current publications. 

Treatment strategy

Investigating the effectiveness of current and modified World Health Organization Guidelines for the control of Soil-Transmitted Helminth infections

Sam H. Farrell et al (2018)

We meld analyses based on 2 mathematical models of parasite transmission and control by MDA for the dominant STH species, to generate a unified treatment approach applicable across all settings, regardless of which STH infection is most common. We recommend clearly defined changes to the current WHO guidelines.

Strategies to improve treatment coverage in community-based public health programs: A systematic review of the literature

Katrina V. Deardorff et al (2018)

The purpose of this systematic review is to evaluate the impact of strategies used to increase treatment coverage in community-based public health campaigns.

Prospects for elimination of soil-transmitted helminths

Kristjana Hrönn Ásbjörnsdóttir et al (2018)

This review summarizes the prospects for switching from control to an elimination strategy.

Sustaining progress towards NTD elimination: an opportunity to leverage lymphatic filariasis elimination programs to interrupt transmission of soil-transmitted helminths

Arianna Rubin Means (2016)

We identify specific rationale, opportunities, and challenges associated with leveraging existing LF elimination platforms for the purpose of interrupting STH transmission.

Modelling

Assessing the interruption of the transmission of human helminths with mass drug administration alone: optimizing the design of cluster randomized trials

Roy Anderson et al (2017)

A method is outlined for the use of an individual-based stochastic model of parasite transmission dynamics to assess different designs for a cluster randomized trial in which mass drug administration (MDA) is employed in attempts to eliminate the transmission of soil-transmitted helminths (STH) in defined geographic locations.

The past matters: estimating intrinsic hookworm transmission intensity in areas with past mass drug administration to control lymphatic filariasis

Marleen Werkman et al (2017)

To design the optimal MDA intervention to eliminate STH infections, it is vital to have information on historical MDA programmes and baseline prevalence to estimate the intrinsic transmission intensity for the defined setting (R0).

Identifying optimal threshold statistics for elimination of hookworm using a stochastic simulation model

James E. Truscott et al (2017)

We develop a simulation of an elimination study, based on the DeWorm3 project, using an individual- based stochastic disease transmission model in conjunction with models of MDA, sampling, diagnostics and the construction of study clusters. The simulation is then used to analyse the relationship between the study end-point elimination threshold and whether elimination is achieved in the long term within the model.

The importance of patient compliance in repeated rounds of mass drug administration (MDA) for the elimination of intestinal helminth transmission

Sam H. Farrell (2017)

Here we develop an individual-based stochastic model of helminth transmission and MDA treatment to investigate how different patterns of compliance influence the impact of MDA for two groups of helminths, the soil transmitted nematode infections and the schistosome parasites.

Soil-transmitted helminths: mathematical models of transmission, the impact of mass drug administration and transmission elimination criteria

James E. Truscott et al (2016)

In this chapter, we review the underlying biology and epidemiology of the three causative intestinal nematode species that are mostly considered under the STH umbrella term. We review efforts to model the transmission cycle of these helminths in populations and the effects of preventative chemotherapy on their control and elimination.

Diagnostics

Diagnostic tools for soil-transmitted helminths control and elimination programs: A pathway for diagnostic product development

Mark D. Lim et al (2018)

This report shares a user-centered framework developed by key opinion leaders convened by the Bill & Melinda Gates Foundation to define circumstances in which population-level diagnostic data could guide an STH program manager’s decision to transition a program to the next phase. The use-cases and companion target product profiles (TPPs) are intended to provide the community with a pathway for the research, development, evaluation, and implementation of diagnostic tools designed for STH programs. This framework can also be used to prioritize research or product development resources based on immediate and anticipated program needs.

A comparative analysis of preservation techniques for the optimal molecular detection of hookworm DNA in a human fecal specimen

Marina Papaiakovou et al (2018)

A comprehensive and systematic assessment of methods for maintaining and preserving soil-transmitted helminth (STH) DNA, particularly from fragile eggs subjected to nuclease exposure in stool.  This study compares preservation methods utilizing human stool aliquots spiked with known concentrations of STH egg material.

Testing for soil-transmitted helminth transmission elimination: Analysing the impact of the sensitivity of different diagnostic tools

Marleen Werkman et al (2018)

This paper quantifies how the sensitivity of Kato-Katz and qPCR affect the optimal prevalence threshold at which to declare the interruption of transmission with a defined level of confidence. 

Pharmacology

Assessment of serum pharmacokinetics and urinary excretion of albendazole and its metabolites in human volunteers

Laura Ceballos et al (2018)

This paper characterizes the serum disposition kinetics and pattern of urinary excretion of ABZ and its main metabolites in humans, and the assessment of the duration and optimal time point where ABZ and/or its metabolites can be measured in urine as an indirect assessment of an individual’s adherence to treatment.

Safety and pharmacokinetic profile of fixed-dose ivermectin with an innovative 18mg tablet in healthy adult volunteers

Jose Muñoz et al (2018)

This study evaluates the safety and pharmacokinetic profile of 3 dosing regimens of invermectin in healthy adults in 3 weight groups. Its role in the treatment of STH through improved efficacy against Trichuris trichiura in combination with other anthelmintics might accelerate the progress towards breaking transmission. 

Combined effectiveness of anthelmintic chemotherapy and WASH among HIV-infected adults

Arianna Rubin Means et al (2018)

This paper evaluates the impact of different potential helminth protective packages on infection prevalence, including repeated treatment with albendazole and praziquantel with and without WASH access.

Life cycle

Seasonally timed treatment programs for Ascaris lumbricoide sto increase impact—An investigation using mathematical models

Emma L. Davis et al (2018)

A new model framework reflecting four key stages of the A. lumbricoides life cycle, incorporating the effects of rainfall and temperature, is used to describe the level of infection in the human population alongside the environmental egg dynamics.

Geographical distribution of soil transmitted helminths and the effects of community type in South Asia and South East Asia – A systematic review

Zachary A. Silver et al (2018)

This study analyses the geographical distribution and effect of community type on prevalence of hookworm, Trichuris and Ascaris in south Asia and south east Asia.

 

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