About

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 A community worker talks to adults about mass drug administration for soil-transmitted helminths in Zanzibar ©GSK

The World Health Organization (WHO) estimates more than 1.5 billion people are infected with soil-transmitted helminths (STHs) worldwide. That is: 

24percentpopulation

The DeWorm3 approach

DeWorm3 is testing the feasibility of interrupting the transmission of STH infections and to develop feasible, effective strategies for scaling-up transmission interruption programs.

One approach to interrupting the STH transmission cycle and prevent ongoing transmission to children is to broadly administer community-wide the deworming drug albendazole to people of all age groups in these areas.

New modelling of STH transmission dynamics, suggests that it may be possible to interrupt the transmission of STH using chemotherapy alone – with an “intensified” community-wide MDA strategy.

We will test the principal hypothesis:

  • Three years of community-wide treatment with albendazole will be sufficient to interrupt transmission of each individual species in the same areas, whereas programmes targeted at pre-school and school-age children will not achieve such interruption. 
DeWorm3 Endpoint Scenarios.© Arianna Means, DeWorm3

DeWorm3 Endpoint Scenarios.© Arianna Means, DeWorm3

References

 Anderson R, Truscott J, Hollingsworth TD (2014) The coverage and frequency of mass drug administration required to eliminate persistent transmission of soil-transmitted helminths  Philos Trans R Soc Lond B Bio Sci 369: 20130435.

Background

Learn about the disease and its symptoms and how the WHO currently treats intestinal worms