An image of an ant's brain infected by parasites, captured by the Museum's Imaging and Analysis Centre.

An image depicting the brain of a blood raiding ant (Formica aserva) infected by parasites, captured by the Museum's Imaging and Analysis Centre.

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New research reveals what happens inside an ant's brain infected with a parasitic worm

New research by the Natural History Museum has revealed what happens inside an ant's brain when it is infected with a parasitic worm.

Scientists used the Museum's Imaging and Analysis Centre to scan the ant's heads and bodies using a micro-CT scanner, producing new images of this behaviour for the first time. 

The flatworm also known as the lancet liver fluke is a parasite with a remarkable life cycle. During the course of its life it inhabits snails, ants and herbivorous mammals like cattle, and although it is miniscule, it is capable of mind control.

The life cycle

The lancet liver fluke starts life similarly to many other parasites, as an egg living in the dung of sheep and cattle. That waste is eaten by a snail, which becomes the parasite's first host. The egg lodges inside the snail's gut, where larvae hatch and develop. The parasite is eventually ejected in the snail's slime ball, which is in turn eaten by an ant.

Now in their second host one of the parasitic flatworm lodges itself inside the ant's brain and effectively takes over, controlling the helpless ant's behaviour. The rest of the parasitic individuals wait in the ant's abdomen.

The mind control extends to leading the ant directly into harm's way. At dusk, the ant will be compelled to walk to the top of blades of grass or other vegetation and lock their jaws to it. In this position, they are most likely to be eaten by herbivores in the early morning.

This will happen every night until the ant is eaten by a host in which the parasite can fully mature.

Adult liver flukes reproduce inside the animal's bile duct and eggs are excreted out with the dung, starting the whole process again.

Co-author of the paper Dr Martin Hall says, 'This is an extraordinary lifecycle, and a classic example of a parasite manipulating a host to its own advantage. This kind of behaviour has fascinated biologists for years. However, the mechanisms that parasites use to manipulate the ants' behaviour are unknown – partly because until now we haven't been able to see the physical relationship between the parasite and the ant's brain.'

Capturing the images

The images captured, for the first time, allowed scientists to see what is happening when the flatworm lodges in the ant's brain.

It is a picture of the specific region where the neurons responsible for the mandibular closure muscles are found. These muscles are the ones which the ants use to clamp on to grass.

Obtaining these images was not easy due to the ants having hard heads and fragile brain tissue. Scientists used the Museum's Imaging and Analysis Centre to scan the ant's heads and bodies using a micro-CT scanner.

The scanner is capable of 'dissecting' an ant's brain in a non-invasive way, allowing scientists to see inside the brain from various angles. Up until now, other traditional examination techniques couldn't show this, hindering scientists' understanding of how the parasite manipulates the behaviour of the ant.

The ants were collected from a site in Alberta in Canada, stored in vials of ethanol, and shipped to the Museum for study.

Dr Daniel Martín-Vega, a Scientific Associate at the Museum who led the CT scanning study, says, 'Modern imaging tools can revolutionise our understanding of key processes that happen when a parasite meets a host. We could see the infestation in the brain for the first time, and confirmed that there could be up to three brain worms in one ant.

There have been previous reports of more than one parasite lodged in the brain. This study shows that in the case of multiple infections, only one of them actually makes contact with the brain tissue.'

The images also show that a sucker is needed to actively manipulate the ant.

Dr Martín-Vega adds, 'This study shows the potential of micro-CT scanning in parasitology. It could be very useful for both research and education, as it gives the opportunity to directly visualise a parasite and its interaction with the tissues of the host.'

The paper has been published in the journal Scientific Reports.


Notes for editors

Images and video: Please download and credit as specified. (Link not for publication.)

Interview: Dr Martín-Vega and Dr Martin Hall are happy to be contacted for comment.

Media contact: Tel: +44 (0) 20 7942 5654/+44 (0) 7799 690151 Email:

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