The Molecular lab team
Head of division
Raju joined the NHM as Head of Division in 2017. With a PhD in Bioinformatics, Genomics and Proteomics from the University of York, Raju started his career as a bioinformatician with organisation such as GSK, HPA and the University of Oxford. Later becoming deputy head of Genomics Research at PHE. Since joining the NHM he now works on applied biomedical and environmental R&D.
Andie has worked in Molecular labs at the NHM since 2004, first in Entomology, then Zoology. With a BSc in Zoology & MSc in wildlife management from the University of Reading, she began her career in R&D of pharmaceuticals. Andie’s focus is on HTS (Illumina & nanopore) for researchers, students & commercial projects. She works on all sample types from environmental to tissue, eukaryote & prokaryote, though specialises in insects.
Laboratory assistant (Darwin Tree of Life project)
Clementine joined at the end of September 2020 and her main role will be to barcode sequence samples and collections for the Darwin Tree of Life. She obtained a BSc in Biomedical Sciences and before joining the NHM she worked at the Wellcome Centre for Human Genetics, maintaining labs and equipment as part of the Facilities Team and has had 3 year of lab experience in a HTS facility at the Oxford Genomics Centre.
Molecular biology assistant
Ramin joined the Core Research Laboratories in April 2021. He graduated from the University of Reading in Physiology and Biochemistry in 1986 and obtained a Ph.D. in Pharmacology in from Cardiff University, where he studied hormone-dependent breast cancer. He then embarked on postdoctoral periods of research in Florence, Houston, Paris and London and followed this by delivering a genomics service at Cancer Research UK. Most recently he was involved in SARS-CoV-2 genomics research at the University of Cambridge.
Ranbir’s primary focus is lab operations (facility management, health & safety, user support), but she also carries out research on NHM collections. She obtained a BSc in Biomedical Science & MSc in Biomedical Research from King’s College London, starting her career working on the genetics of breast cancer at the Ludwig Institute, UCL. She later worked on the development of clinical grade lentiviral vectors to target cancer at UCL’s Division of Infection & Immunity, before moving into divisional lab management.
With an BSc Honours Degree in Applied Biology, Claire came to the Museum in 1999 after working in Pathology & Oncology at Charing Cross Hospital. She is the Senior Sanger Sequencing Technician, specialising in DNA extraction from difficult or degraded material. She is a key figure in the operation and management of high throughput pipelines, undertaking frequent commercial projects. Claire liaises closely with staff and students- providing support and training in various technologies and techniques.
Molecular biologist (Implementation)
Sarah joined the museum in 2018 after completing her PhD in Molecular Microbiology at Royal Holloway, University of London. After working initially to cover both R&D and lab operations, she is now a specialist in next generation sequencing technologies and helps to support the work of NHM researchers through development of new innovative methods in genomics and molecular biology. She is currently working on applying robotic automation to a range of different sequencing applications and assists on museum-wide projects, including Urban Nature Project and Darwin Tree of Life.
Senior molecular biologist
Dr Darren Chooneea completed a PhD in infectious diseases, microbiology, and proteomics at Public Health England. He is currently based at the NHM within the Molecular Laboratories. He is involved in numerous projects working on a range of sample types from human stool, FFPE samples, various tissues, hair, blood, and various environmental samples. He enjoys public engagement, method development, and pushing the limits of technology.
Silvia’s primary focus is developing computational pipelines to analyse sequencing data from several applications, including DNA metabarcoding, functional transcriptomics, and de novo assemblies. Before joining the NHM, she earned a PhD in Bioinformatics in Switzerland and spent five years working at the Wellcome Centre for Human Genetics in Oxford.
Elena has been part of the Team since 2015 working in both lab operations & research. She has a degree in biochemistry and a DPhil in fungal pathogens from the University of Oxford, continuing her academic career at New York University’s medical centre & the Kennedy Institute, University of Oxford. While at the museum she has worked on an incredible range of diverse species, though parasites and pathogens remain her favourites.
Research assistant (DARPA project)
Piotr joined the Molecular Biology Lab Team in August 2020. His primary focus within the lab will be on development, validation and optimization of a new method for characterization of air-borne pathogens with the application of next-generation sequencing. Piotr has a PhD in Biomedical Sciences, his thesis investigated ticks and certain tick-borne pathogens. After his PhD graduation he was continuing his work with ticks as the Research Associate at the University of Gdansk, then as a Research Scientist at the Pirbright Institute working with mosquito gene drive systems.
Molecular lab selected publications
Comparative Genomics Analysis Demonstrated a Link Between Staphylococci Isolated from Different Sources: A Possible Public Health Risk. (2021). Cave, R., Raju, M., Chen, J., Wang, S. and Mkrtchyan, H.V. Frontiers in Microbiology (12)257 DOI 10.3389/fmicb.2021.576696
DEFRA Centre of Excellence for DNA Methods: Evaluation of DNA barcode libraries used in the UK and developing an action plan to fill priority gaps. Natural England Joint Publication JP035. (2020). Ben Price, Andy Briscoe, Raju Misra and Gavin Broad https://nhm.openrepository.com/handle/10141/622857
The levels of sICAM-1, sELAM-1, TNFα and sTNFR1 proteins in patients with colorectal adenocarcinoma in tumor and corresponding normal mucosa (2020).Joanna Katarzyna Strzelczyk, Piotr Cuber, Benjamin Bochon, Krzysztof Gajdzik, Janusz Strzelczyk, Łukasz Krakowczyk, Andrzej Wiczkowski, Aleksander Jerzy Owczarek and Zofia Ostrowska. Acta Biochimica Polonica Epub: No 5449. Vol. 67. https://doi.org/10.18388/abp.2020_5449
Mitochondrial and plastid genome variability of Corallina officinalis (Corallinales, Rhodophyta) (2020) Chris Yesson, Xueni Bian, Christopher Williamson, Andrew G Briscoe & Juliet Brodie Applied Phycology, 1:1, 73-9, DOI: 10.1080/26388081.2020.1827940
Treatments for Lipid Oxidation in Taxidermy and Impact on DNA Recovery (2020) Lu Allington-Jones & Ranbir Bailey Studies in conservation. DOI: 10.1080/00393630.2020.1855858
Development of a Molecular Snail Xeno-monitoring Assay to Detect Schistosoma haematobium and Schistosoma bovis Infections in their Bulinus Snail Hosts. 2020. Tom Pennance, John Archer, Elena Birgitta Lugli, Penny Rostron ,Felix Llanwarne, Said Mohammed Ali, Amour Khamis Amour,Khamis Rashid Suleiman, Sarah Li , David Rollinson, Jo Cable, Stefanie Knopp, Fiona Allan, Shaali Makame Ame and Bonnie Lee Webster. Molecules 2020, 25, 4011; doi:10.3390/molecules25174011
Metabarcoding unsorted kick-samples facilitates macroinvertebrate-based biomonitoring with increased taxonomic resolution, while outperforming environmental DNA (2020) Lyndall Pereira-da-Conceicoa, Vasco Elbrecht, Andie Hall, Andrew Briscoe, Helen Barber-James, Benjamin Price. Environmental DNA. 2020;00:1–19. DOI: 10.1002/edn3.116
The first mitochondrial genomes of endosymbiotic rhabdocoels illustrate evolutionary relaxation of atp8 and genome plasticity in flatworms (2020). Marlies Monnens, SofieThijs, Andrew G Briscoe et al. International Journal of Biological Macromolecules Volume 162, 1 November 2020, Pages 454- 469. https://doi.org/10.1016/j.ijbiomac.2020.06.025
Polaszek A, Noyes JS, Russell S, Ramadan MM (2020) Metaphycus macadamiae (Hymenoptera: Encyrtidae) – a biological control agent of macadamia felted coccid Acanthococcus ironsidei (Hemiptera: Eriococcidae) in Hawaii. PLoSONE 15(4):e0230944. https://doi.org/10.1371/journal.pone.0230944
The increased sensitivity of qPCR in comparison to Kato-Katz is required for the accurate assessment of the prevalence of soil-transmitted helminth infection in settings that have received multiple rounds of mass drug administration. Dunn, JC. Papaiakovou, M. Thwe Han, K. Chooneea, D…Misra, R. et al. Parasites & Vectors volume 13, Article number: 324 (2020) doi: 10.1186/s13071-020-04197-w
Redefining Pyropia (Bangiales, Rhodophyta): Four New Genera, Resurrection of Porphyrella and Description of Calidia pseudolobata sp. nov. From China (2020). Li En Yang, Yin Yin Deng, Guang Ping Xu, Stephen Russell, Qin Qin Lu, Juliet Brodie . Journal of Phycology https://doi.org/10.1111/jpy.12992
Equivocal Evidence for Colony Level Stress Effects on Bumble Bee Pollination Services. (2020) Arran Greenop, Nevine Mica-Hawkyard, Sarah Walkington, Andrew Wilby, Samantha M Cook, Richard F Pywell and Ben A Woodcock. Insects , 11, 191; doi:10.3390/insects11030191
Comparative Proteomic Profiling of Methicillin-Susceptible and Resistant Staphylococcus aureus. (2020) Xu Z, Chen J, Vougas K, Shah A, Shah H, Misra R, Mkrtchyan HV Proteomics. Jan;20(2):e1900221. doi: 10.1002/pmic.201900221.
Novel Methicillin-Resistant Staphylococcus aureus CC8 Clone Identified in a Hospital Setting in Armenia. (2019) Jamrozy D, Misra R, Xu Z, Ter-Stepanyan MM, Kocharyan KS, Cave R, Hambardzumyan AD, Mkrtchyan HV. Microbiology. DOI: 10.3389/fmicb.2019.01592
Pooling as a strategy for the timely diagnosis of soil transmitted helminths in stool: value and reproducibility. Marina Papaiakovou, James Wright, Nils Pilotte, Darren Chooneaa et al. (2019). Parasites and Vectors. DOI:10.1186/s13071-019-3693-3
Integrated Approach Reveals Role of Mitochondrial Germ-Line Mutation F18L in Respiratory Chain, Oxidative Alterations, Drug Sensitivity, and Patient Prognosis in Glioblastoma (2019). Kathleen Keatley ,Samuel Stromei-Cleroux ,Tammy Wiltshire ,Nina Rajala,Gary Burton,William V. Holt,D. Timothy J. Littlewood, Andrew G. Briscoe et al International Journal of Molecular Sciences 20(13):3364. DOI: 10.3390/ijms20133364
Deep-Sea anthropogenic macrodebris harbours rich and diverse communities of bacteria and archaea. (2018) Woodall, L.C., Jungblut, A.D., Hopkins, K., Hall. A., Robinson, L.F., Gwinnett, C., Paterson, G.L.J. Plos One. doi.org/10.1371/journal.pone.0206220