The circular shape and large, flush periproct of Amblypygus resembles Holectypus, but the circular, notched peristome of Holectypus is quite different (Cooke, 1959, p. 27). The peristome and periproct of Amblypygus appears to be very similar to Echinoneus. These genera only differ in that the ambulacra of Echinoneus are less distinctly petaloid, with the outer pores not as transversely elongated as they are in Amblypygus.
Amblypygus can be differentiated from pygaulids by its poorly developed (undifferentiated) phyllodes, which contain only a single offset series of pores in each column.
Agassiz, L. 1840. Catalogus systematicus Ectyporum Echinodermatum fossilium Musei Neocomiensis, secundum ordinem zoologicum dispositus; adjectis synonymis recentioribus, nec non stratis et locis in quibus reperiuntur. Sequuntur characteres diagnostici generum novorum vel minus cognitorum, 20 pp. Oliv. Petitpierre, Neuchâtel.
C. W. Cooke. 1959. Cenozoic echinoids of eastern United States. United States Geological Survey, Professional Paper, 321, 106 pp., 43 pls.
J. Lambert & P. Thiery. 1909-1925. Essai de nomenclature raisonnee des echinides. Libraire Septime Ferriere, Chaumont, 607 pp., 15 pls.
Srivastava, D. K. 2009. Taxonomic placement of a holectypoid echinoid genus Srivastava & Singh, 2001. Earth Science India 2:46-51.