Hydroxylapatite (HAP) nanoparticles
AFM image of HAP aggregates
The reactivity and potential toxicity of HAP nanoparticles
Hydroxylapatite is a commonly used biomaterial as it is also the mineral component of bones and teeth. Because of their biomedical applications, the physicochemical properties of HAP nanoparticles need to be tested to avoid any toxic effects when introduced in the body.
Project aim
To investigate potential links between toxicity and the physicochemical properties of HAP nanoparticles, as expressed in relevant media, to allow selection of the safest and most biocompatible forms of HAP in future biomedical and other applications.
Objectives
- Phase 1:
Synthesise HAP nanoparticles with different size, composition and Ca:P stoichiometry in the context of different pH, temperature, ionic strength and the presence of amino acids (triethanolamine and o-phospho-L-serine). - Phase 2:
- Assess the reactivity/chemical stability of nanoparticles by measuring solubility, surface charge and agglomeration in different media containing relevant proteins and aminoacids.
- Conduct toxicity experiments to establish whether a link exists between reactivity of the HAP nanoparticles and toxic behaviour.
Primary investigator
- Éva Valsami-Jones (Natural History Museum)
Post-doctoral research fellow
- Corinna Skartsila (Natural History Museum)
