April 09 - present
Laboratory Manager, Molecular Laboratories Life Science,
The Natural History Museum,
July 07 – April 09
Laboratory Manager, Molecular Systematics Laboratory,
Department of Entomology,
The Natural History Museum,
May 03 – July 07
Laboratory Manager/Senior Technician/Safety Officer
Department of Immunity and Inflammation, Kennedy Institute of Rheumatology,
Aug 01 – May 03
Senior Scientific Officer
Developmental Signalling Laboratory, Cancer Research UK,
Dec 99 – Aug 01
Novartis Horsham Research Centre,
July 96 – Dec 99
Clinical Scientist Grade A
Coagulation Research Laboratory,
Haemophilia Centre, St Thomas Hospital,
Dec 94 - July 96
Dept. of Experimental Pathology,
UMDS, Guy's Hospital,
June 92 - Dec 94
Dept. of Gene Structure & Expression, National Institute for Medical Research,
Nov 89 - June 92
Dept. of Genetic Toxicology, BIBRA International,
2003 NEBOSH certificate in Health and Safety
Pass with distinction,
Imperial College, London.
1995 B.Sc. Biotechnology 1st Class with Honours
North East Surrey College of Technology,
Epsom and Ewell.
1991 HNC in Applied Biology Distinction
North East Surrey College of Technology, Epsom and Ewell.
David L. Moyes, Alex Martin, Stephen Sawcer, Nigel Temperton, Jane Worthington,
David J. Griffiths, Patrick J. Venables (2005).
The distribution of the endogenous retroviruses HERV-K113 and
HERV-K115 in health and disease. (Genomics 86 337– 341)
Yatin M. Patel, Kirti Patel, Salman Rahman, Gillian Spooner, Rushika Sumathipala, Michael Mitchel, Geraldine Flynn, Alexandra Aitken, Geoffrey Savidge, Mark Smith. (2003).
Evidence for a role for Gi1 in mediating weak agonist-induced platelet aggregation in human platelets. Reduced Gi1 expression and defective Gi signalling in the platelets of a patient suffering from a chronic bleeding disorder. (Blood 15;101(12), 4828-4835)
Rahman S, Flynn G, Aitken A, Patel Y, Hussain F, Lu X, Loftus JC, French D, Wijelath E, Strand K, Savidge GF. (2000).
Differential recognition of snake venom proteins expressing specific Arg-Gly-Asp (RGD) sequence motifs by wild-type and variant integrin alphaIIbbeta3: further evidence for distinct sites of RGD ligand recognition exhibiting negative allostery. Biochem J 345(3) 701-709
Rahman, S., Aitken, A., Flynn, G., Formstone, C. and Savidge, G.F. (1998).
Modulation of RGD Peptide Motifs Regulates Disintegrin Recognition of αIIbβ3
and a5b1 Integrin Complexes Biochem. J. 335, 247-257.
Aitken, M. A., Raguz, S., Antoniou, M. (1998)
Gene transfer and Expression in Tissue Culture cells of Higher Eukaryotes.
Molecular Biomethods Handbook, Humana Press Inc., Totowa, NJ, USA. Chapter 20 235-250.
Criado, G., Lam, C., Martin, A. and Williams, R. O. (2006)
Expression and activity of indoleamine 2,3 dioxygenase in arthritis
Ann. Rheum. Dis. 65 (Supl 1): A10
Presented at European Workshop for Rheumatology Research.
David Moyes, Alex Martin, Stephen Sawcer, Nigel Temperton, David Griffiths, Patrick Venables
HERV-K113 - A risk factor for multiple sclerosis?
Immunology 2004, 113 (s1), 96-97
Presented at the British Society of Immunology Annual Congress.
David Moyes, Alex Aitken, Stephen Sawcer, David Griffiths, Nigel Temperton, Patrick Venables. (2005).
The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health ans disease: HERV-K113 as a novel risk factor for Sjögren’s syndrome.
Rheumatology, 44 suppl 1: i133-i134
Presented at the British Society of Rheumatology Annual Meeting.
Corteling, R.L., Li, S.W., Aitken, A., Poll, C.T., Westwick, J. & Hall, I.P.(2001)
Transient receptor potential (TRP) expression in human airway smooth muscle cells. Conference: 97th International Conference of The American Thoracic Society, San Francisco, CA, USA. Am J Resp.& Crit Care Med. Supp. 163 (5) A780.
Aitken, A., Flynn, G., Hussain, F., Patel, Y., Savidge, G.F., Rahman, S. (1999)
Engineering of the integrin binding motif RGD (Arg-Gly-Asp) motif into coagulation factor VII. Conference: XVII Congress of the Internatinal Society on Thrombosis and Haemostasis, Washington, D.C., USA.
Patel, Y., Rahman, S., Flynn, G., Aitken, A., Savidge, G.F., Smith, M. (1999)
Defective Gi activation in the platelets of a patient suffering from a chronic bleeding disorder. Conference: XVII Congress of the Internatinal Society on Thrombosis and Haemostasis, Washington, D.C., USA.
Hussain, F., Aitken, A., Flynn, G., Patel, Y., Savidge, G.F., Rahman, S. (1999)
Complex formation between recombinant fragments comprising integrin
aIib residues 1-400 and b3 residues 100-400.
Conference: XVII Congress of
the Internatinal Society on Thrombosis and Haemostasis, Washington, D.C., USA.
Aitken, A., Flynn, G., Lu. X., Loftus, J.C., Savidge G.F., Rahman, S. (1998)
Further evidence for distinct recognition sites on the integrin αIIbβ3
provided by recombinant snake venom RGD proteins.
Conference: Integrins-supplying multidisciplinary approaches for targeted therapies,
January 29-30 1998, Boston, MA, USA.
Flynn, G., Aitken, A, Bajt, M.L., Loftus, J.C., Savidge G.F., Rahman, S. (1997) Characterisation of αIIbβ3 - variant heterodimerss using recombinant RGD proteins. Conference: International Society of Thrombosis and Haemostasis, Florence, Italy.
Rahman, S., Aitken, A, Flynn, G., Lu. X., Boulton, P., Alhaq, A., Newman, P., Jenkins, E., Savidge G.F. (1996)
The amino acid residues flanking the RGD sequence of snake venom platelet aggregation inhibitors modulate the specificity of the integrin-ligand interaction.
Conference: American Society of Haematology, Orlando, FL, USA.
Newman, P., Bonello, F., Flynn, G., Boulton, P., Aitken, A., Rahman, S.,
Alhaq, A., Jenkins, E., Shearer, M., Savidge, G.F. (1996)
Heparin inhibits lipoprotein-mediated transport of Vitamin K into cultures human osteoblasts.
Conference: American Society of Haematology, Orlando, FL, USA