Dr Nathan Kenny

Dr Nathan Kenny

Marie Curie Fellow, ADAPTOMICS

Department: Life Sciences
Division: LS Invertebrates Division
Contact: email
Phone: 020 7942 6475

Summary

I work with a variety of invertebrate Phyla, studying aspects of their biology from a genomic angle. This has included, but is by no means limited to, the study of cold adaptation and regeneration in sponges, the establishment of left/right asymmetry in annelids and molluscs, and the hormonal control of growth and maturation in non-insect arthropods. Presently I am supported by a Marie Skłodowska Curie Fellowship, and am examining the molecular changes that have occurred in Antarctic sponges, when compared to their close relatives from more temperate regions. This will give us a broad insight into the nature of evolutionary pressures in cold climates, as well as hopefully allowing us to predict the likely effects of climate change on these species and their related ecosystems.

Qualifications

Degrees

DPhil, University of Oxford, Oxford, Oxford, 2010 - 2014

BSc (Hons) Genetics, BA Philosophy, University of Otago, Dunedin, Dunedin, 2004 - 2009

Employment history

Academic

MSCA IF Fellow, Invertebrates Division, Natural History Museum, London, Life Sciences, United Kingdom, 2017 - ongoing

Postdoctoral Fellow, Chinese University of Hong Kong, Hong Kong, Hui lab, Hong Kong, 2014 - 2016

Grants

ADAPTOMICS
Role: Principal investigatorKenny NJ, Riesgo A
Funding: H2020 Excellent Science

Publications

Taboada S, Kenny NJ, Riesgo A, Wiklund H, Paterson GLJ, Dahlgren TG, Glover AG (2018) Mitochondrial genome and polymorphic microsatellite markers from the abyssal sponge Plenaster craigi Lim & Wiklund, 2017: tools for understanding the impact of deep-sea mining. Marine Biodiversity, 48 (1) : 621 - 630. doi: 10.1007/s12526-017-0786-0

Kenny NJ, Noreña C, Damborenea C, Grande C (2018) Probing recalcitrant problems in polyclad evolution and systematics with novel mitochondrial genome resources. Genomics, doi: 10.1016/j.ygeno.2018.02.009

Alvarez-Campos P, Kenny NJ, Verdes A, Fernandez RM, Novo M, Giribet G, Riesgo A (2018) Delegating sex: differential gene expression in stolonizing syllids uncovers the hormonal control of reproduction in Annelida. Bioarxiv, doi: 10.1101/271783

Kenny NJ, de Goeij JM, de Bakker DM, Whalen CG, Berezikov E, Riesgo A (2018) Towards the identification of ancestrally shared regenerative mechanisms across the Metazoa: A Transcriptomic case study in the Demosponge Halisarca caerulea. Marine Genomics, 37 : 135 - 147. doi: 10.1016/j.margen.2017.11.001

Kenny NJ, de Goeij JM, de Bakker DM, Whalen CG, Berezikov E, Riesgo A (2017) Ancestrally Shared Regenerative Mechanisms Across the Metazoa: A Transcriptomic Case Study in the Demosponge Halisarca caerulea. bioRxiv, 160689 - 160689. doi: 10.1101/160689

Pechmann M, Benton MA, Kenny NJ, Posnien N, Roth S (2017) A novel role for Ets4 in axis specification and cell migration in the spider Parasteatoda tepidariorum. bioRxiv, 129411 - 129411. doi: 10.1101/160689

Benton MA, Kenny NJ, Conrads KH, Roth S, Lynch JA (2016) Deep, Staged Transcriptomic Resources for the Novel Coleopteran Models Atrachya menetriesi and Callosobruchus maculatus. PLOS ONE, 11 (12) : e0167431 - e0167431. doi: 10.1371/journal.pone.0167431

Kenny NJ, Chan KW, Nong W, Qu Z, Maeso I, Yip HY, Chan TF, Kwan HS, Holland PWH, Chu KH, Hui JHL (2016) Ancestral whole-genome duplication in the marine chelicerate horseshoe crabs. Heredity, 116 (2) : 190 - 199. doi: 10.1038/hdy.2015.89

Kenny NJ, Truchado-García M, Grande C (2016) Deep, multi-stage transcriptome of the schistosomiasis vector Biomphalaria glabrata provides platform for understanding molluscan disease-related pathways. BMC Infectious Diseases, 16 (1) : doi: 10.1186/s12879-016-1944-x

Grande C, Martín-Durán JM, Kenny NJ, Truchado-García M, Hejnol A (2014) Evolution, divergence and loss of the Nodal signalling pathway: new data and a synthesis across the Bilateria. The International Journal of Developmental Biology, 58 (6-7-8) : 521 - 532. doi: 10.1387/ijdb.140133cg

Kenny NJ, Namigai EK, Dearden PK, Hui JH, Grande C, Shimeld SM (2014) The Lophotrochozoan TGF-β signalling cassette - diversification and conservation in a key signalling pathway. The International Journal of Developmental Biology, 58 (6-7-8) : 533 - 549. doi: 10.1387/ijdb.140080nk

Kenny NJ, Namigai EK, Marlétaz F, Hui JH, Shimeld SM (2015) Draft genome assemblies and predicted microRNA complements of the intertidal lophotrochozoans Patella vulgata (Mollusca, Patellogastropoda) and Spirobranchus ( Pomatoceros ) lamarcki (Annelida, Serpulida). Marine Genomics, 24 : 139 - 146. doi: 10.1016/j.margen.2015.07.004

Kenny NJ, Shen X, Chan TT, Wong NW, Chan TF, Chu KH, Lam H-M, Hui JH (2015) Genome of the Rusty Millipede, Trigoniulus corallinus, Illuminates Diplopod, Myriapod, and Arthropod Evolution. Genome Biology and Evolution, 7 (5) : 1280 - 1295. doi: 10.1093/gbe/evv070

Kenny NJ, Sin YW, Hayward A, Paps J, Chu KH, Hui JHL (2015) The phylogenetic utility and functional constraint of microRNA flanking sequences. Proceedings of the Royal Society B: Biological Sciences, 282 (1803) : 20142983 - 20142983. doi: 10.1098/rspb.2014.2983

Qu Z, Kenny NJ, Lam HM, Chan TF, Chu KH, Bendena WG, Tobe SS, Hui JHL (null) How did arthropod sesquiterpenoids and ecdysteroids arise? Comparison of hormonal pathway genes in non-insect arthropod genomes. Genome Biology and Evolution, evv120 - evv120. doi: 10.1093/gbe/evv120

Sin YW, Kenny NJ, Qu Z, Chan KW, Chan KW, Cheong SP, Leung RW, Chan TF, Bendena WG, Chu KH, Tobe SS, Hui JH (2015) Identification of putative ecdysteroid and juvenile hormone pathway genes in the shrimp Neocaridina denticulata. General and Comparative Endocrinology, 214 : 167 - 176. doi: 10.1016/j.ygcen.2014.07.018

Chipman AD, Ferrier DEK, Brena C, Qu J, Hughes DST, Schröder R, Torres-Oliva M, Znassi N, Jiang H, Almeida FC, Alonso CR, Apostolou Z, Aqrawi P, Arthur W, Barna JCJ, Blankenburg KP, Brites D, Capella-Gutiérrez S, Coyle M, Dearden PK, Du Pasquier L, Duncan EJ, Ebert D, Eibner C, Erikson G, Evans PD, Extavour CG, Francisco L, Gabaldón T, Gillis WJ, Goodwin-Horn EA, Green JE, Griffiths-Jones S, Grimmelikhuijzen CJP, Gubbala S, Guigó R, Han Y, Hauser F, Havlak P, Hayden L, Helbing S, Holder M, Hui JHL, Hunn JP, Hunnekuhl VS, Jackson L, Javaid M, Jhangiani SN, Jiggins FM, Jones TE, Kaiser TS, Kalra D, Kenny NJ, Korchina V, Kovar CL, Kraus FB, Lapraz F, Lee SL, Lv J, Mandapat C, Manning G, Mariotti M, Mata R, Mathew T, Neumann T, Newsham I, Ngo DN, Ninova M, Okwuonu G, Ongeri F, Palmer WJ, Patil S, Patraquim P, Pham C, Pu L-L, Putman NH, Rabouille C, Ramos OM, Rhodes AC, Robertson HE, Robertson HM, Ronshaugen M, Rozas J, Saada N, Sánchez-Gracia A, Scherer SE, Schurko AM, Siggens KW, Simmons D, Stief A, Stolle E, Telford MJ, Tessmar-Raible K, Thornton R, van der Zee M, von Haeseler A, Williams JM, Willis JH, Wu Y, Zou X, Lawson D, Muzny DM, Worley KC, Gibbs RA, Akam M, Richards S (2014) The First Myriapod Genome Sequence Reveals Conservative Arthropod Gene Content and Genome Organisation in the Centipede Strigamia maritima. PLoS Biology, 12 (11) : e1002005 - e1002005. doi: 10.1371/journal.pbio.1002005

Kenny N, Sin Y, Shen X, Zhe Q, Wang W, Chan T, Tobe S, Shimeld S, Chu K, Hui J (2014) Genomic Sequence and Experimental Tractability of a New Decapod Shrimp Model, Neocaridina denticulata. Marine Drugs, 12 (3) : 1419 - 1437. doi: 10.3390/md12031419

Namigai EKO, Kenny NJ, Shimeld SM (2014) Right across the tree of life: The evolution of left–right asymmetry in the Bilateria. genesis, 52 : 458 - 470. doi: 10.1002/dvg.22748.

Wilson MJ, Kenny NJ, Dearden PK (2014) Components of the dorsal-ventral pathway also contribute to anterior-posterior patterning in honeybee embryos (Apis mellifera). EvoDevo, 5 (1) : 11 - 11. doi: 10.1186/2041-9139-5-11

Kenny NJ, Dearden PK (2013) NMDA receptor expression and C terminus structure in the rotifer Brachionus plicatilis and long-term potentiation across the Metazoa. Invertebrate Neuroscience, 13 (2) : 125 - 134. doi: 10.1007/s10158-013-0154-0

Kenny NJ, Quah S, Holland PW, Tobe SS, Hui JH (2013) How are comparative genomics and the study of microRNAs changing our views on arthropod endocrinology and adaptations to the environment?. General and Comparative Endocrinology, 188 : 16 - 22. doi: 10.1016/j.ygcen.2013.02.013

Kenny NJ, Shimeld SM (2012) Additive multiple k-mer transcriptome of the keelworm Pomatoceros lamarckii (Annelida; Serpulidae) reveals annelid trochophore transcription factor cassette. Development Genes and Evolution, 222 (6) : 325 - 339. doi: 10.1007/s00427-012-0416-6

Courses taught

Short course: Molecular diagnostics for species identification and evolutionary analysis

Short course: Integrating molecules with taxonomy and systematics

Introduction

Summary

I work with a variety of invertebrate Phyla, studying aspects of their biology from a genomic angle. This has included, but is by no means limited to, the study of cold adaptation and regeneration in sponges, the establishment of left/right asymmetry in annelids and molluscs, and the hormonal control of growth and maturation in non-insect arthropods. Presently I am supported by a Marie Skłodowska Curie Fellowship, and am examining the molecular changes that have occurred in Antarctic sponges, when compared to their close relatives from more temperate regions. This will give us a broad insight into the nature of evolutionary pressures in cold climates, as well as hopefully allowing us to predict the likely effects of climate change on these species and their related ecosystems.

Qualifications

Degrees

DPhil, University of Oxford, Oxford, Oxford, 2010 - 2014

BSc (Hons) Genetics, BA Philosophy, University of Otago, Dunedin, Dunedin, 2004 - 2009

Employment history

Academic

MSCA IF Fellow, Invertebrates Division, Natural History Museum, London, Life Sciences, United Kingdom, 2017 - ongoing

Postdoctoral Fellow, Chinese University of Hong Kong, Hong Kong, Hui lab, Hong Kong, 2014 - 2016

Projects

Grants

ADAPTOMICS
Role: Principal investigatorKenny NJ, Riesgo A
Funding: H2020 Excellent Science

Publications

Publications

Taboada S, Kenny NJ, Riesgo A, Wiklund H, Paterson GLJ, Dahlgren TG, Glover AG (2018) Mitochondrial genome and polymorphic microsatellite markers from the abyssal sponge Plenaster craigi Lim & Wiklund, 2017: tools for understanding the impact of deep-sea mining. Marine Biodiversity, 48 (1) : 621 - 630. doi: 10.1007/s12526-017-0786-0

Kenny NJ, Noreña C, Damborenea C, Grande C (2018) Probing recalcitrant problems in polyclad evolution and systematics with novel mitochondrial genome resources. Genomics, doi: 10.1016/j.ygeno.2018.02.009

Alvarez-Campos P, Kenny NJ, Verdes A, Fernandez RM, Novo M, Giribet G, Riesgo A (2018) Delegating sex: differential gene expression in stolonizing syllids uncovers the hormonal control of reproduction in Annelida. Bioarxiv, doi: 10.1101/271783

Kenny NJ, de Goeij JM, de Bakker DM, Whalen CG, Berezikov E, Riesgo A (2018) Towards the identification of ancestrally shared regenerative mechanisms across the Metazoa: A Transcriptomic case study in the Demosponge Halisarca caerulea. Marine Genomics, 37 : 135 - 147. doi: 10.1016/j.margen.2017.11.001

Kenny NJ, de Goeij JM, de Bakker DM, Whalen CG, Berezikov E, Riesgo A (2017) Ancestrally Shared Regenerative Mechanisms Across the Metazoa: A Transcriptomic Case Study in the Demosponge Halisarca caerulea. bioRxiv, 160689 - 160689. doi: 10.1101/160689

Pechmann M, Benton MA, Kenny NJ, Posnien N, Roth S (2017) A novel role for Ets4 in axis specification and cell migration in the spider Parasteatoda tepidariorum. bioRxiv, 129411 - 129411. doi: 10.1101/160689

Benton MA, Kenny NJ, Conrads KH, Roth S, Lynch JA (2016) Deep, Staged Transcriptomic Resources for the Novel Coleopteran Models Atrachya menetriesi and Callosobruchus maculatus. PLOS ONE, 11 (12) : e0167431 - e0167431. doi: 10.1371/journal.pone.0167431

Kenny NJ, Chan KW, Nong W, Qu Z, Maeso I, Yip HY, Chan TF, Kwan HS, Holland PWH, Chu KH, Hui JHL (2016) Ancestral whole-genome duplication in the marine chelicerate horseshoe crabs. Heredity, 116 (2) : 190 - 199. doi: 10.1038/hdy.2015.89

Kenny NJ, Truchado-García M, Grande C (2016) Deep, multi-stage transcriptome of the schistosomiasis vector Biomphalaria glabrata provides platform for understanding molluscan disease-related pathways. BMC Infectious Diseases, 16 (1) : doi: 10.1186/s12879-016-1944-x

Grande C, Martín-Durán JM, Kenny NJ, Truchado-García M, Hejnol A (2014) Evolution, divergence and loss of the Nodal signalling pathway: new data and a synthesis across the Bilateria. The International Journal of Developmental Biology, 58 (6-7-8) : 521 - 532. doi: 10.1387/ijdb.140133cg

Kenny NJ, Namigai EK, Dearden PK, Hui JH, Grande C, Shimeld SM (2014) The Lophotrochozoan TGF-β signalling cassette - diversification and conservation in a key signalling pathway. The International Journal of Developmental Biology, 58 (6-7-8) : 533 - 549. doi: 10.1387/ijdb.140080nk

Kenny NJ, Namigai EK, Marlétaz F, Hui JH, Shimeld SM (2015) Draft genome assemblies and predicted microRNA complements of the intertidal lophotrochozoans Patella vulgata (Mollusca, Patellogastropoda) and Spirobranchus ( Pomatoceros ) lamarcki (Annelida, Serpulida). Marine Genomics, 24 : 139 - 146. doi: 10.1016/j.margen.2015.07.004

Kenny NJ, Shen X, Chan TT, Wong NW, Chan TF, Chu KH, Lam H-M, Hui JH (2015) Genome of the Rusty Millipede, Trigoniulus corallinus, Illuminates Diplopod, Myriapod, and Arthropod Evolution. Genome Biology and Evolution, 7 (5) : 1280 - 1295. doi: 10.1093/gbe/evv070

Kenny NJ, Sin YW, Hayward A, Paps J, Chu KH, Hui JHL (2015) The phylogenetic utility and functional constraint of microRNA flanking sequences. Proceedings of the Royal Society B: Biological Sciences, 282 (1803) : 20142983 - 20142983. doi: 10.1098/rspb.2014.2983

Qu Z, Kenny NJ, Lam HM, Chan TF, Chu KH, Bendena WG, Tobe SS, Hui JHL (null) How did arthropod sesquiterpenoids and ecdysteroids arise? Comparison of hormonal pathway genes in non-insect arthropod genomes. Genome Biology and Evolution, evv120 - evv120. doi: 10.1093/gbe/evv120

Sin YW, Kenny NJ, Qu Z, Chan KW, Chan KW, Cheong SP, Leung RW, Chan TF, Bendena WG, Chu KH, Tobe SS, Hui JH (2015) Identification of putative ecdysteroid and juvenile hormone pathway genes in the shrimp Neocaridina denticulata. General and Comparative Endocrinology, 214 : 167 - 176. doi: 10.1016/j.ygcen.2014.07.018

Chipman AD, Ferrier DEK, Brena C, Qu J, Hughes DST, Schröder R, Torres-Oliva M, Znassi N, Jiang H, Almeida FC, Alonso CR, Apostolou Z, Aqrawi P, Arthur W, Barna JCJ, Blankenburg KP, Brites D, Capella-Gutiérrez S, Coyle M, Dearden PK, Du Pasquier L, Duncan EJ, Ebert D, Eibner C, Erikson G, Evans PD, Extavour CG, Francisco L, Gabaldón T, Gillis WJ, Goodwin-Horn EA, Green JE, Griffiths-Jones S, Grimmelikhuijzen CJP, Gubbala S, Guigó R, Han Y, Hauser F, Havlak P, Hayden L, Helbing S, Holder M, Hui JHL, Hunn JP, Hunnekuhl VS, Jackson L, Javaid M, Jhangiani SN, Jiggins FM, Jones TE, Kaiser TS, Kalra D, Kenny NJ, Korchina V, Kovar CL, Kraus FB, Lapraz F, Lee SL, Lv J, Mandapat C, Manning G, Mariotti M, Mata R, Mathew T, Neumann T, Newsham I, Ngo DN, Ninova M, Okwuonu G, Ongeri F, Palmer WJ, Patil S, Patraquim P, Pham C, Pu L-L, Putman NH, Rabouille C, Ramos OM, Rhodes AC, Robertson HE, Robertson HM, Ronshaugen M, Rozas J, Saada N, Sánchez-Gracia A, Scherer SE, Schurko AM, Siggens KW, Simmons D, Stief A, Stolle E, Telford MJ, Tessmar-Raible K, Thornton R, van der Zee M, von Haeseler A, Williams JM, Willis JH, Wu Y, Zou X, Lawson D, Muzny DM, Worley KC, Gibbs RA, Akam M, Richards S (2014) The First Myriapod Genome Sequence Reveals Conservative Arthropod Gene Content and Genome Organisation in the Centipede Strigamia maritima. PLoS Biology, 12 (11) : e1002005 - e1002005. doi: 10.1371/journal.pbio.1002005

Kenny N, Sin Y, Shen X, Zhe Q, Wang W, Chan T, Tobe S, Shimeld S, Chu K, Hui J (2014) Genomic Sequence and Experimental Tractability of a New Decapod Shrimp Model, Neocaridina denticulata. Marine Drugs, 12 (3) : 1419 - 1437. doi: 10.3390/md12031419

Namigai EKO, Kenny NJ, Shimeld SM (2014) Right across the tree of life: The evolution of left–right asymmetry in the Bilateria. genesis, 52 : 458 - 470. doi: 10.1002/dvg.22748.

Wilson MJ, Kenny NJ, Dearden PK (2014) Components of the dorsal-ventral pathway also contribute to anterior-posterior patterning in honeybee embryos (Apis mellifera). EvoDevo, 5 (1) : 11 - 11. doi: 10.1186/2041-9139-5-11

Kenny NJ, Dearden PK (2013) NMDA receptor expression and C terminus structure in the rotifer Brachionus plicatilis and long-term potentiation across the Metazoa. Invertebrate Neuroscience, 13 (2) : 125 - 134. doi: 10.1007/s10158-013-0154-0

Kenny NJ, Quah S, Holland PW, Tobe SS, Hui JH (2013) How are comparative genomics and the study of microRNAs changing our views on arthropod endocrinology and adaptations to the environment?. General and Comparative Endocrinology, 188 : 16 - 22. doi: 10.1016/j.ygcen.2013.02.013

Kenny NJ, Shimeld SM (2012) Additive multiple k-mer transcriptome of the keelworm Pomatoceros lamarckii (Annelida; Serpulidae) reveals annelid trochophore transcription factor cassette. Development Genes and Evolution, 222 (6) : 325 - 339. doi: 10.1007/s00427-012-0416-6

Teaching and students

Courses taught

Short course: Molecular diagnostics for species identification and evolutionary analysis

Short course: Integrating molecules with taxonomy and systematics