Dr Ariane Standing

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Postdoctoral Researcher, Leverhulme Novelty

Department: Life Sciences
Division: LS Vertebrates Division

Qualifications

Degrees

PhD Genetics of Autoinflammation, UCL, London, 2008 - 2012

MSc Integrative Biosciences, University of Oxford, Oxford, 2007 - 2008

MA Natural Sciences with Zoology, University of Cambridge, Cambridge, 2003 - 2006

Employment history

Academic

Postdoctoral Researcher, The Natural History Museum, Life Sciences, UK, 2016 - 2019

Postdoctoral Research Fellow, University of Bedfordshire, School of Life Sciences, United Kingdom, 2015 - 2016

Postdoctoral Research Fellow, UCL and Great Ormond St Institute of Child Health, United Kingdom, 2012 - 2015

Non-academic

Sierra Leone Ebola Lab Volunteer, Public Health England, Sierra Leone, 2016 - 2016

Sierra Leone Ebola Lab Volunteer, Public Health England, Sierra Leone, 2015 - 2015

Publications

Leal DV, et. al. (2018) Endocrine, immune and inflammatory adaptations in men following exercise-induced chronic stress. Annals of Research in Sport and Physical Activity, 91 - 92. doi: 10.14195/2182-7087_ex2018_22

Omoyinmi E, Standing A, Keylock A, Price-Kuehne F, Melo Gomes S, Rowczenio D, Nanthapisal S, Cullup T, Nyanhete R, Ashton E, Murphy C, Clarke M, Ahlfors H, Jenkins L, Gilmour K, Eleftheriou D, Lachmann HJ, Hawkins PN, Klein N, Brogan PA (2017) Clinical impact of a targeted next-generation sequencing gene panel for autoinflammation and vasculitis. PLOS ONE, 12 (7) : e0181874 - e0181874. doi: 10.1371/journal.pone.0181874

Standing A (2017) Thrombocytopaenia: A Defect in Actin Dynamics?. null,

Nanthapisal S, Omoyinmi E, Murphy C, Standing A, Eisenhut M, Eleftheriou D, Brogan PA (2017) Early-Onset Juvenile SLE Associated With a Novel Mutation in Protein Kinase C δ. Pediatrics, 139 (1) : e20160781 - e20160781. doi: 10.1542/peds.2016-0781

Standing AS, Malinova D, Hong Y, Record J, Moulding D, Blundell MP, Nowak K, Jones H, Omoyinmi E, Gilmour KC, Medlar A, Stanescu H, Kleta R, Anderson G, Nanthapisal S, Gomes SM, Klein N, Eleftheriou D, Thrasher AJ, Brogan PA (2017) Autoinflammatory periodic fever, immunodeficiency, and thrombocytopenia (PFIT) caused by mutation in actin-regulatory gene WDR1. The Journal of Experimental Medicine, 214 (1) : 59 - 71. doi: 10.1084/jem.20161228

Nanthapisal S, Murphy C, Omoyinmi E, Hong Y, Standing A, Berg S, Ekelund M, Jolles S, Harper L, Youngstein T, Gilmour K, Klein NJ, Eleftheriou D, Brogan PA (2016) Deficiency of Adenosine Deaminase Type 2: A Description of Phenotype and Genotype in Fifteen Cases. Arthritis & Rheumatology, 68 (9) : 2314 - 2322. doi: 10.1002/art.39699

Omoyinmi E, Standing A, Keylock A, Rowczenio D, Melo Gomes S, Cullup T, Jenkins L, Gilmour K, Eleftheriou D, Lachmann H, Hawkins P, Klein N, Brogan P (2016) SAT0010 A Targeted Next-Generation Sequencing Gene Panel for Autoinflammation. Annals of the Rheumatic Diseases, 75 (Suppl 2) : 667.2 - 667. doi: 10.1136/annrheumdis-2016-eular.3837

Omoyinmi E, Melo Gomes S, Nanthapisal S, Woo P, Standing A, Eleftheriou D, Klein N, Brogan PA (2015) Stimulator of Interferon Genes-Associated Vasculitis of Infancy. Arthritis & Rheumatology, 67 (3) : 808 - 808. doi: 10.1002/art.38998

Gomes S, Arostegui J, Omoyinmi E, Standing A, Klein N, Lachmann H, Hawkins P, Brogan P (2015) Whole Exome Sequencing reveals a NLRP3 mutation in exon 5 in a patient with CINCA. Pediatric Rheumatology, 13 (Suppl 1) : P45 - P45. doi: 10.1186/1546-0096-13-S1-P45

Nanthapisal S, Murphy C, Omoyinmi E, Standing A, Hong Y, Gomes S, Klein N, Eleftheriou D, Brogan P (2015) Monogenic polyarteritis nodosa caused by ADA2 Deficiency: the GOSH experience. Pediatric Rheumatology, 13 (Suppl 1) : P8 - P8. doi: 10.1186/1546-0096-13-S1-P8

Rowczenio D, Gomes S, Aróstegui J, Omoyinmi E, Gonzalez-Roca E, Standing A, Eleftheriou D, Klein N, Brogan P, Lachmann H, Hawkins P (2015) Late onset of the cryopyrin-associated periodic syndrome (CAPS) associated with low level of somatic mosaicism in six patients. Pediatric Rheumatology, 13 (Suppl 1) : P37 - P37. doi: 10.1186/1546-0096-13-S1-P37

Standing A, Eleftheriou D, Paisan-Ruiz C, Rowcenzio D, Hong Y, Omoyinmi E, Woo P, Hawkins P, Lachmann H, Klein N, Brogan P (2015) Loss of function mutation in a mitochondrial chaperone protein leading to dyregulated ROS production, and autoinflammatory disease in a single kindred. Pediatric Rheumatology, 13 (Suppl 1) : O1 - O1. doi: 10.1186/1546-0096-13-S1-O1

Standing A, Malinova D, Record J, Moulding D, Blundell M, Nowak K, Jones H, Omoyinmi E, Nanthapisal S, Gomes S, Hong Y, Klein N, Eleftheriou D, Thrasher A, Brogan P (2015) Severe autoinflammatory disease caused by mutation in a gene controlling actin cytoskeletal dynamics and cure with allogeneic haematopoetic stem cell transplantation. Pediatric Rheumatology, 13 (Suppl 1) : O19 - O19. doi: 10.1186/1546-0096-13-S1-O19

Gomes S, Arostegui J, Omonyinmi E, Gonzalez-Roca E, Standing A, Rowczenio D, Nathanpisal S, Murphy C, Elephteriou D, Klein N, Hawkins P, Lachmann H, Brogan P (2014) The role of somatic NLRP3 mosaicism and new gene discovery in mutation negative cryopyrin-associated periodic syndrome patients. Pediatric Rheumatology, 12 (Suppl 1) : P70 - P70. doi: 10.1186/1546-0096-12-S1-P70

Omoyinmi E, Melo Gomes S, Standing A, Rowczenio DM, Eleftheriou D, Klein N, Aróstegui JI, Lachmann HJ, Hawkins PN, Brogan PA (2014) Brief Report: Whole-Exome Sequencing Revealing Somatic NLRP3 Mosaicism in a Patient With Chronic Infantile Neurologic, Cutaneous, Articular Syndrome. Arthritis & Rheumatology, 66 (1) : 197 - 202. doi: 10.1002/art.38217

Standing A, Paisan-Ruiz C, Eleftheriou D, Hong Y, Omoyinmi E, Rowcenzio D, Lachmann H, Hawkins P, Woo P, Klein N, Brogan P (2014) Identification of a novel monogenic autoinflammatory disease due to mutation in a mitochondrial chaperone protein in a single kindred, and cure with allogeneic haematopoietic stem cell transplantation. Pediatric Rheumatology, 12 (Suppl 1) : O22 - O22. doi: 10.1186/1546-0096-12-S1-O22

Standing A, Omoyinmi E, Brogan P (2013) Gene hunting in autoinflammation. Clinical and Translational Allergy, 3 (1) : 32 - 32. doi: 10.1186/2045-7022-3-32

Standing A, Eleftheriou D, Omoyinmi E, Chieng A, Klein N, Lachmann H, Hawkins P, Gilmour K, Brogan P (2012) A Novel Mutation in the X-Linked Inhibitor of Apoptosis Protein Causing a Multi-System Autoinflammatory Disorder. Annals of Paediatric Rheumatology, 1 (4) : 227 - 227. doi: 10.5455/apr.012920120432

Standing ASI, Eleftheriou D, Lachmann HJ, Brogan PA (2011) Comment on: Familial Mediterranean fever caused by homozygous E148Q mutation complicated by Budd-Chiari syndrome and polyarteritis nodosa: reply. Rheumatology, 50 (7) : 1349 - 1350. doi: 10.1093/rheumatology/ker170

Standing ASI, Eleftheriou D, Lachmann HJ, Brogan PA (2011) Familial Mediterranean fever caused by homozygous E148Q mutation complicated by Budd-Chiari syndrome and polyarteritis nodosa. Rheumatology, 50 (3) : 624 - 626. doi: 10.1093/rheumatology/keq405

Standing ASI, Yánez DC, Ross R, Crompton T, Furmanski AL (2017) Frontline Science: Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma. Journal of Leukocyte Biology, 102 (4) : 965 - 976. doi: 10.1189/jlb.3HI1016-438RR

Courses taught

Second year: Genetics

1/2018 - 8/2018.

Third year: Applications of Immunology

3/2017 - 8/2017.

MSc: Laboratory skills in cardiovascular research - Cloning

3/2016.

Course developed

Co developers: Standing A
Laboratory skills in cardiovascular research - Cloning,
2/3/2016

Introduction

Qualifications

Degrees

PhD Genetics of Autoinflammation, UCL, London, 2008 - 2012

MSc Integrative Biosciences, University of Oxford, Oxford, 2007 - 2008

MA Natural Sciences with Zoology, University of Cambridge, Cambridge, 2003 - 2006

Employment history

Academic

Postdoctoral Researcher, The Natural History Museum, Life Sciences, UK, 2016 - 2019

Postdoctoral Research Fellow, University of Bedfordshire, School of Life Sciences, United Kingdom, 2015 - 2016

Postdoctoral Research Fellow, UCL and Great Ormond St Institute of Child Health, United Kingdom, 2012 - 2015

Non-academic

Sierra Leone Ebola Lab Volunteer, Public Health England, Sierra Leone, 2016 - 2016

Sierra Leone Ebola Lab Volunteer, Public Health England, Sierra Leone, 2015 - 2015

Publications

Publications

Leal DV, et. al. (2018) Endocrine, immune and inflammatory adaptations in men following exercise-induced chronic stress. Annals of Research in Sport and Physical Activity, 91 - 92. doi: 10.14195/2182-7087_ex2018_22

Omoyinmi E, Standing A, Keylock A, Price-Kuehne F, Melo Gomes S, Rowczenio D, Nanthapisal S, Cullup T, Nyanhete R, Ashton E, Murphy C, Clarke M, Ahlfors H, Jenkins L, Gilmour K, Eleftheriou D, Lachmann HJ, Hawkins PN, Klein N, Brogan PA (2017) Clinical impact of a targeted next-generation sequencing gene panel for autoinflammation and vasculitis. PLOS ONE, 12 (7) : e0181874 - e0181874. doi: 10.1371/journal.pone.0181874

Standing A (2017) Thrombocytopaenia: A Defect in Actin Dynamics?. null,

Nanthapisal S, Omoyinmi E, Murphy C, Standing A, Eisenhut M, Eleftheriou D, Brogan PA (2017) Early-Onset Juvenile SLE Associated With a Novel Mutation in Protein Kinase C δ. Pediatrics, 139 (1) : e20160781 - e20160781. doi: 10.1542/peds.2016-0781

Standing AS, Malinova D, Hong Y, Record J, Moulding D, Blundell MP, Nowak K, Jones H, Omoyinmi E, Gilmour KC, Medlar A, Stanescu H, Kleta R, Anderson G, Nanthapisal S, Gomes SM, Klein N, Eleftheriou D, Thrasher AJ, Brogan PA (2017) Autoinflammatory periodic fever, immunodeficiency, and thrombocytopenia (PFIT) caused by mutation in actin-regulatory gene WDR1. The Journal of Experimental Medicine, 214 (1) : 59 - 71. doi: 10.1084/jem.20161228

Nanthapisal S, Murphy C, Omoyinmi E, Hong Y, Standing A, Berg S, Ekelund M, Jolles S, Harper L, Youngstein T, Gilmour K, Klein NJ, Eleftheriou D, Brogan PA (2016) Deficiency of Adenosine Deaminase Type 2: A Description of Phenotype and Genotype in Fifteen Cases. Arthritis & Rheumatology, 68 (9) : 2314 - 2322. doi: 10.1002/art.39699

Omoyinmi E, Standing A, Keylock A, Rowczenio D, Melo Gomes S, Cullup T, Jenkins L, Gilmour K, Eleftheriou D, Lachmann H, Hawkins P, Klein N, Brogan P (2016) SAT0010 A Targeted Next-Generation Sequencing Gene Panel for Autoinflammation. Annals of the Rheumatic Diseases, 75 (Suppl 2) : 667.2 - 667. doi: 10.1136/annrheumdis-2016-eular.3837

Omoyinmi E, Melo Gomes S, Nanthapisal S, Woo P, Standing A, Eleftheriou D, Klein N, Brogan PA (2015) Stimulator of Interferon Genes-Associated Vasculitis of Infancy. Arthritis & Rheumatology, 67 (3) : 808 - 808. doi: 10.1002/art.38998

Gomes S, Arostegui J, Omoyinmi E, Standing A, Klein N, Lachmann H, Hawkins P, Brogan P (2015) Whole Exome Sequencing reveals a NLRP3 mutation in exon 5 in a patient with CINCA. Pediatric Rheumatology, 13 (Suppl 1) : P45 - P45. doi: 10.1186/1546-0096-13-S1-P45

Nanthapisal S, Murphy C, Omoyinmi E, Standing A, Hong Y, Gomes S, Klein N, Eleftheriou D, Brogan P (2015) Monogenic polyarteritis nodosa caused by ADA2 Deficiency: the GOSH experience. Pediatric Rheumatology, 13 (Suppl 1) : P8 - P8. doi: 10.1186/1546-0096-13-S1-P8

Rowczenio D, Gomes S, Aróstegui J, Omoyinmi E, Gonzalez-Roca E, Standing A, Eleftheriou D, Klein N, Brogan P, Lachmann H, Hawkins P (2015) Late onset of the cryopyrin-associated periodic syndrome (CAPS) associated with low level of somatic mosaicism in six patients. Pediatric Rheumatology, 13 (Suppl 1) : P37 - P37. doi: 10.1186/1546-0096-13-S1-P37

Standing A, Eleftheriou D, Paisan-Ruiz C, Rowcenzio D, Hong Y, Omoyinmi E, Woo P, Hawkins P, Lachmann H, Klein N, Brogan P (2015) Loss of function mutation in a mitochondrial chaperone protein leading to dyregulated ROS production, and autoinflammatory disease in a single kindred. Pediatric Rheumatology, 13 (Suppl 1) : O1 - O1. doi: 10.1186/1546-0096-13-S1-O1

Standing A, Malinova D, Record J, Moulding D, Blundell M, Nowak K, Jones H, Omoyinmi E, Nanthapisal S, Gomes S, Hong Y, Klein N, Eleftheriou D, Thrasher A, Brogan P (2015) Severe autoinflammatory disease caused by mutation in a gene controlling actin cytoskeletal dynamics and cure with allogeneic haematopoetic stem cell transplantation. Pediatric Rheumatology, 13 (Suppl 1) : O19 - O19. doi: 10.1186/1546-0096-13-S1-O19

Gomes S, Arostegui J, Omonyinmi E, Gonzalez-Roca E, Standing A, Rowczenio D, Nathanpisal S, Murphy C, Elephteriou D, Klein N, Hawkins P, Lachmann H, Brogan P (2014) The role of somatic NLRP3 mosaicism and new gene discovery in mutation negative cryopyrin-associated periodic syndrome patients. Pediatric Rheumatology, 12 (Suppl 1) : P70 - P70. doi: 10.1186/1546-0096-12-S1-P70

Omoyinmi E, Melo Gomes S, Standing A, Rowczenio DM, Eleftheriou D, Klein N, Aróstegui JI, Lachmann HJ, Hawkins PN, Brogan PA (2014) Brief Report: Whole-Exome Sequencing Revealing Somatic NLRP3 Mosaicism in a Patient With Chronic Infantile Neurologic, Cutaneous, Articular Syndrome. Arthritis & Rheumatology, 66 (1) : 197 - 202. doi: 10.1002/art.38217

Standing A, Paisan-Ruiz C, Eleftheriou D, Hong Y, Omoyinmi E, Rowcenzio D, Lachmann H, Hawkins P, Woo P, Klein N, Brogan P (2014) Identification of a novel monogenic autoinflammatory disease due to mutation in a mitochondrial chaperone protein in a single kindred, and cure with allogeneic haematopoietic stem cell transplantation. Pediatric Rheumatology, 12 (Suppl 1) : O22 - O22. doi: 10.1186/1546-0096-12-S1-O22

Standing A, Omoyinmi E, Brogan P (2013) Gene hunting in autoinflammation. Clinical and Translational Allergy, 3 (1) : 32 - 32. doi: 10.1186/2045-7022-3-32

Standing A, Eleftheriou D, Omoyinmi E, Chieng A, Klein N, Lachmann H, Hawkins P, Gilmour K, Brogan P (2012) A Novel Mutation in the X-Linked Inhibitor of Apoptosis Protein Causing a Multi-System Autoinflammatory Disorder. Annals of Paediatric Rheumatology, 1 (4) : 227 - 227. doi: 10.5455/apr.012920120432

Standing ASI, Eleftheriou D, Lachmann HJ, Brogan PA (2011) Comment on: Familial Mediterranean fever caused by homozygous E148Q mutation complicated by Budd-Chiari syndrome and polyarteritis nodosa: reply. Rheumatology, 50 (7) : 1349 - 1350. doi: 10.1093/rheumatology/ker170

Standing ASI, Eleftheriou D, Lachmann HJ, Brogan PA (2011) Familial Mediterranean fever caused by homozygous E148Q mutation complicated by Budd-Chiari syndrome and polyarteritis nodosa. Rheumatology, 50 (3) : 624 - 626. doi: 10.1093/rheumatology/keq405

Standing ASI, Yánez DC, Ross R, Crompton T, Furmanski AL (2017) Frontline Science: Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma. Journal of Leukocyte Biology, 102 (4) : 965 - 976. doi: 10.1189/jlb.3HI1016-438RR

Teaching and students

Courses taught

Second year: Genetics

1/2018 - 8/2018.

Third year: Applications of Immunology

3/2017 - 8/2017.

MSc: Laboratory skills in cardiovascular research - Cloning

3/2016.

Course developed

Co developers: Standing A
Laboratory skills in cardiovascular research - Cloning,
2/3/2016