Microgale talazaci is rated as Least Concern (IUCN, 2009) in view of its wide distribution, presumed large population, presence in a number of protected areas, and because it is unlikely to be declining fast enough to qualify for listing in a more threatened category. Nevertheless, as for much of the fauna of Madagascar, there are potential long-term threats to the species from habitat loss and fragmentation caused by conversion of forest to agricultural land, logging activities and fire.