There is no legislation protecting Dynastes neptunus and it is not considered a seriously threatened species.

However, because deforestation is a serious problem through much of the species’ range, there should be concern about the shrinking areas of suitable forest still remaining, particularly on the western Andean slopes which are most threatened by human activities.

The species is very popular with insect breeders and collectors, but such activities are of minor importance to its survival compared to habitat loss.