The Studies of Humoral Immunity in Rabbits Vaccinated with Ultraviolet-Attenuated Cercariae of Schistosoma japonicum.

XIE Wenyue¹, LIU Guozhang² and CHEN Xiaoguang².
¹ Dept. of Clinical Lab., General Military Hospital in Guangzhou Area, 510010 China.
² Dept. of Parasitology, the First Military Medical University , Guangzhou 510515 China

Rabbits were vaccinated multiply with ultraviolet-attenuated cercariae of Schistosoma japonicum,of which the levels of IgG antibody in serum were observed dynamically.At the same time, sera with vaccinated rabbits transfered passively to mice at different time to detect the resistant.The results showed the levels of IgG antibody was detected 2 weeks after vaccination,peaked by 5 weeks and attenuated rabbit sera confered significant levels of protection(51%) when transfered before challenge. This suggested that antibody might play an important role in the protective immunity elicited by uv-attenuated Schistosoma japonicum cercariae mutiply.

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created 21/12/00