SONG Wen-jian and GHENG Yu-li
Department of Parasitology,
Medical College of Jianghan University, Wuhan, China
Aim: To study the relationship between schistosomiasis japonica and the infection with HBV.
Method: 216 patients with schistosomiasis japonica were studied, 190 of them with chronic schistosomiasis japonica and 26 patients in late stage were confirmed by physical examination, the rectoscopy and ultrasonoscope. All patients were tested with the diagnostic kit of HbsAg.
Results: 87 (40.3%) cases were in cirrhosis and 33 (15.3%) cases showed hepatitis B antigenemia among 216 cases. 23 of 87 (26.4%) cases with cirrhosis were positive in HbsAg test. 10 of 129 (7.75%) cases without cirrhosis were positive in HbsAg. 13 of 26 (50%) cases with late schistosomiasis japonica were positive in HbsAg test. The rate of HBV infection is higher in the patients with schistosomiasis japonica than that in the population without Schistosoma japonicum infection (15.3%: 8.5%) and the rate of HBV infection is higher in the patients with cirrhosis than that without cirrhosis. It is highest in the patients with later schistosomiasis.
Discussion: The higher infection rate of HBV in the patients with schistosomiasis japonica may be involved in the immunity of the host, generally, the patients with schistosomiasis have an impaired immune response. The current studies suggest that a "pure" Schistosoma japonicum infection is not involved in cirrhosis and the coexisiting hepatitis B may be a major cause of cirrhosis in the patients with schistosomiasis. Also it is possible that the infection of HBV accelerates the development of schistosomaisis from the earlier stage to late stage.
 |
|
|
|||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
| 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| 31 | 32 | 33 | 34 | 35 | 36 | 37 | 38 | ||
created 21/12/00
